Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study

Abstract Objectives Diabetes induces osteoporosis and during osteoporosis, vertebral bone marrow (VBM) adipose tissue amount increases. The association between this adiposity and bone marrow metabolism is unclear. Here, we compared VBM glucose metabolism and fat content in healthy and diabetic pigs, in vivo , using positron emission tomography (PET), in-phase and out-of-phase magnetic resonance imaging and magnetic resonance proton spectroscopy ( 1 H MR spectroscopy). Materials/methods Eleven pigs (n = 11) were used. The intervention group had five diabetic and the control group had six healthy pigs. To measure metabolism, PET-imaging with [ 18 F]fluoro-deoxy-glucose ([ 18 F]FDG) intravenous tracer was used. 1.5-T MRI with 1 H spectroscopy, in-phase and out-of-phase imaging and chemical TAG analysis of the VBM were performed. Results We found a significant inverse correlation between VBM glucose uptake (GU) and VBM fat content (R = − 0.800, p p 1 H MR spectroscopy and TAG concentration (R = 0.661) and 1 H MR spectroscopy and in-phase and out-of-phase MR imaging (R = 0.635). Conclusions VBM glucose metabolism coupled with VBM fat content may impact diabetic induced osteoporosis.