vaccination in Autoimmune Animal Models

d ifferent studies have proved the concept of autoimmune/ inflammatory syndrome induced by adjuvants (ASIA) in animal models [1]. Hence, vaccination remains a concern especially in genetically susceptible patients or those with immune mediated diseases such as systemic lupus erythematosus (SLE), as autoimmune diseases can be triggered by environmental factors. Therefore, it is important to determine if the use of vaccines or adjuvants in susceptible populations can initiate or aggravate the course of these diseases. For this reason, analyzing environmental effects in animal models is a good approach to identify risk in this particular population.