A CROSS-SECTIONAL SURVEY TO DETERMINE THE ACCURACY OF PLATELETS DIAGNOSTICS AND SPLEEN TO COUNT DIAMETER RATIO TO IDENTIFY ESOPHAGEAL VARICES WITHIN CHORIONIC LIVER DISEASES DUE TO HEPATITIS-C

Objective: This study was focused on determining the diagnostics platelet accuracy, count to spleen ratio of diameter for the existence of oesophageal varices within patients with chronic liver disease which is secondary to Hepatitis C taking endoscopy as the gold standard. Method: It was Cross-sectional survey, held at Services Hospital, Lahore in the timeframe of six months starting from November 2017 to April 2018. Non-probability sampling technique was utilized. After obtaining an informed consent from the patients, 182 patients satisfying medical case definition of Chronic Liver Diseases secondary to Hepatitis C were incorporated in the research study. Upper GIT endoscopy was carried out in compliance with standard procedure and oesophageal varices equivalent and above 5mm was taken as a positive value. Complete blood count (CBC) was carried out for the measurement of platelet in number/microliter (µl) and measurement of spleen diameter in (mm) was done through abdominal ultrasonography (USG). Results: A total number of 182 patients with CLD secondary to HCV participated in the study. The mean age range among participants was 50.76±12.88 years. The gender ratio was 47.8% males and 52.2% females as comprising over 87 males and 95 females out of 182 patients. The EVs were observed present in 96 (53%) and absent in 86 (47.8%) patients in the Upper GIT endoscopy. The patients Average PC/SD ratio including varices was 831.0288 and in absence, it was 1358.4155. The patients average PC/SD ratio was 1080.0730. The PC/SD ratio’s specificity and sensitivity in compliance to the accuracy of diagnostics was 58.9% and 71.7% respectively. The positive and negative predictive values were 66% and 65% respectively and EVs prediction was 65.7% in accordance with diagnostic accuracy related to PC/SD ratio. Conclusion: The ratio of PC/SD is non significantly linked with the prediction of oesophagal varices with 65.7% accuracy of diagnostics. Keywords: Platelet Count to Spleen diameter ratio, oesophagal varices, Chronic liver disease, Hepatitis C