S1225 Fecal Osteoprotegerin: A Marker for Pediatric Ulcerative Colitis At Diagnosis - a Pilot Study

SMO levels in involved UC rectal tissues versus uninvolved right colon in a group of patients with left-sided colitis. There was an increase in SMO levels from 0.75 ± 0.21 to 2.63 ± 0.94 x 1019 copies, which represented a 3.5-fold increase (n = 10, p = 0.006 by paired t test). Conclusions: In general, SMO mRNA expression is increased in UC tissues. The increase was more marked in tissues with quiescent or mild colitis than in tissues from moderate or severe colitis. This pattern suggests that like ODC, SMO expression and polyamine metabolism also vary depending on disease activity. Assessment of SMO levels is important in understanding dysregulated polyamine homeostasis in UC and may prove useful as a marker of early or mild UC.