Association analysis of GAS5 polymorphisms and psoriasis

Abstract Psoriasis is a complex disorder with genetic background. Previous studies have reported the presence of some genetically-influenced factors for this disorder. In the current study, we genotyped rs2067079 and rs6790 polymorphisms of GAS5 lncRNA in Iranian patients with psoriasis and healthy controls. Genotype frequencies of rs2067079 and rs6790 were in accordance with the Hardy-Weinberg equilibrium both in cases and controls. Distributions of alleles/genotypes of rs2067079 and rs6790 polymorphisms were similar between patients with psoriasis and healthy controls. None of these SNPS were associated with risk of psoriasis in any inheritance model. We also appraised association between GAS5 haplotypes and risk of psoriasis. Frequencies of CG, TG, CA and TA haplotypes (rs2067079 and rs6790) were statistically similar between patients with psoriasis and healthy controls. Thus, mentioned polymorphisms are not associated with risk of psoriasis in Iranian population.