Design and modeling of a prototype fiber scanning CARS endoscope
2010
An endoscope capable of Coherent Anti-Stokes Raman scattering (CARS) imaging would be of significant clinical value
for improving early detection of endoluminal cancers. However, developing this technology is challenging for many
reasons. First, nonlinear imaging techniques such as CARS are single point measurements thus requiring fast scanning in
a small footprint if video rate is to be achieved. Moreover, the intrinsic nonlinearity of this modality imposes several
technical constraints and limitations, mainly related to pulse and beam distortions that occur within the optical fiber and
the focusing objective.
Here, we describe the design and report modeling results of a new CARS endoscope. The miniature microscope
objective design and its anticipated performance are presented, along with its compatibility with a new spiral scanningfiber
imaging technology developed at the University of Washington. This technology has ideal attributes for clinical
use, with its small footprint, adjustable field-of-view and high spatial-resolution. This compact hybrid fiber-based
endoscopic CARS imaging design is anticipated to have a wide clinical applicability.
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