Improved preparation and separated purification method of benzimidazole type proton pump inhibitors and precursor thereof

The present invention provides a process for preparing benzimidazole-type proton pump inhibitors and their precursors, such as omeprazole, rabeprazole, lansoprazole, ilaprazole and the like, separation and purification methods. During the synthesis after the first pull azoles and their precursors by the addition of a surfactant or a phase transfer catalyst, to accelerate the reaction rate, the reaction is more complete, the reaction selectivity and efficiency, a single product is more easy product deal with. This method overcomes the poor reproducibility of the prior methods, yields and product purity instability drawback, complicated post-processing solution, crystallization difficult issues.