Consequence of lead on the histology of the cerebellum of the brain of adultAlbino rat

Background: Lead is one of the common environmental contaminant. Lead poisoning can affect the various cognitive and behavioral function of the brain and cerebellum is one of the main part of brain concerning to the cognitive function. That’s why this study is intended to find the Consequence of lead on the histology of the cerebellum of the brain of adult Albino rat. Methods: Twelve adult albino rats of Charles Foster strain (6 experimental and 6 control groups) were used as the experimental animal in the present study. After 21 days exposure of lead, albino rats were sacrificed and tissue perfusion was done. Sectioning of tissues and H & Ex staining was done and viewed under microscope. Results: swollen and degenerated Purkinje cells which were decreased in number, Some pyknotic cells showed pericellular clearing. Numerous hyperchromatic and pyknotic granular cells were also seen with edematous molecular cell layers and showed spongiosis of the grey matter with focal proliferation of capillaries and necrosis. Conclusion: Grey matter showed spongiosis and focal proliferation of the capillaries along with necrosis.