Вплив поліоксипропіленгліколю молекулярної маси 500 у субтоксичних дозах на рецепторний апарат і внутрішньоклітинний метаболізм

The influence of polyoxipropilenglycole with 500 molecular mass under long-term subtoxic action on receptor apparatus and intracellular cyclase mediator cascade system under subacute experiment on warm-blooded animals were studied. There are revealed guanylate cyclase increased activity in the liver and inhibition of adenylate cyclase on the background of the cGMP content enlargment and cAMP reduction under the influence of Laprol in dose 1/100 DL50. The xenobiotics subtoxic action on 45Ca2+ absorption by hepatocyte microsomal membrane preparations synaptosom neuronal synaptosomes of the cerebral cortex have been studied. The increase in this indicator both in the liver and in the brain have been showed. It is showed, that L-502-2-10 in 1/100 DL50 had increased adrenoreceptor dissociation constant and maximal seating capacity of receptor binding in the cerebral cortex.