Effect of Antacids and Sucralfate on the Pharmacokinetics of Roxatidine

The effects of co-administration of antacid (Maaloxreg; 15ml) and sucralfate (1g) on the pharmacokinetic actions of roxatidine acetate (75mg), a typical histamine H2 antagonist, were evaluated in six healthy volunteers following a meal. After the coadministration of roxatidine and sucralfate or antacid, no significant difference was demonstrated in the pharmacokinetics of roxatidine. However, when sucralfate administered together with roxatidine before the meal, the pharmacokinetic actions of roxatidine were significantly decreased compared to roxatidine alone. There was no effect in the absorption of roxatidine, when Maaloxreg; and sucralfate were taken by oral administration.