High-dose chemotherapy plus autologous stem cell transplation (HDCT/ SCT) in patients with sarcoma: A single institution experience.

10042 Background: Chemotherapy is the standard treatment in high risk advanced sarcomas. The role of HDCT/SCT is controversial in this patients (pt). We described our experience and long term results in sarcoma patients treated into a compassionate use program. Methods: From 12/1988 to 09/2007, 22 pt (16 male, 6 female) with advanced undifferentiated round cell soft tissue or bone sarcoma (15 (68%) Ewing S, 7 (32%) rhabdomyosarcoma) underwent HDCT/SCT; 10 pt had advanced locoregional sarcomas, 12 pt metastatic disease at onset.A minimum of 4x106 CD34+/kg cells were collected. 18 pt received conditioning HDCT regimen with (cyclophosphamide 1500 mg/m2, carboplatin 350 mg/m2, etoposide 400 mg/m2) iv x 3 d.; In 4 pt treated with double HDCT/SCT (tandem), conditioning was ifosfamide 2,500 mg/m2, carboplatin 360 mg/m2, etoposide 310 mg/m2 iv × 4 d. Only pts with CR and maximum PR to previous treatments were included (17 RC, 5 PR). One PR pt was included with an early progression before 1st ASCT. Eighteen pt rec...