Фактор роста и дифференцировки GDF-15 в сыворотке крови беременных женщин при физиологической и осложненной тяжелым гестозом беременности

According to contemporary experimental data, GDF-15 protein levels may be anticipated to be increased in pre-eclampsia, though data regarding this topic are scarce and contradictory. Thus, we determined levels of growth and differentiation factor 15 (GDF-15) protein in serum of pre-eclamptic (N=8) and healthy (N=37) pregnant women (38-40 weeks gestation). Serum GDF-15 levels were determined using ELISA kit. : Median GDF-15 was 181,212.0 pg/ml in the control group and 177,850.5 pg/ml in pre-eclamptic patients. No significant differences were found between the groups, thus we concluded GDF-15 not to be of major-effect nature in pre-eclampsia pathogenesis or etiology. However, GDF-15 level disturbances may have minor-effect nature in this pregnancy complications, and respective-design type investigations are further required to answer this question.