Hypercalciuria in pediatric patients with ureteropelvic junction obstruction is of genetic origin

Objective. Genitourinary tract malformations are associated with urolithiasis. Hypercalciuria has been described in children with ureteropelvic junction obstruction (UPJO), although the etiology of this metabolic abnormality remains unknown. This study was conducted to find out whether children with UPJO have a higher prevalence of hypercalciuria and whether their family members are affected by hypercalciuria and/or urolithiasis. Material and methods. We studied the prevalence of hypercalciuria and urolithiasis in 27 children (14 males, 13 females) with UPJO and their parents. Results. One patient had a history of renal colic, whereas imaging studies showed macroscopic renal lithiasis in two patients and calyceal microlithiasis in four. Hypercalciuria was found in 17/27 children (63%), 15 of whom (88%) had a familial history of urolithiasis: seven families in first-degree relatives, six in second-degree relatives and two in other relatives. Concerning the 10 children without hypercalciuria, seven of them ...