Subacute Phase of Stroke Treated with Ganglioside GM1
1986
Various effects of treatment with GM1 ganglioside were shown:
a)
enhancement of neuronal sprouting and neuritogenesis (potentiating the effects of trophic factors) (Cotman et al., 1981; Gorio et al., 1980; Wojcik et al., 1982; Toffano et al., 1983; Ferrari et al., 1983);
b)
functional recovery of dopaminergic and cholinergic activity after lesion (Toffano et al., 1983);
c)
reduction of cerebral edema (Karpiak, 1983);
d)
prevention of progressive neural damage following trauma by means of complex intracellular mechanisms (activation of membrane bound enzymes) (Seifert, 1981).
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