Frequent inactivation of A20 in B-cell lymphomas

A20 is a negative regulator of the NF-κB pathway and has a pivotal role in regulation of the immune response. Using a genome-wide analysis of genetic lesions in B-cell lymphomas, A20 is shown to be a common genetic target in B-lineage lymphomas, with uncontrolled NF-κB signalling caused by loss of A20 function implicated in the pathogenesis of subsets of these lymphomas.