The Molecular Genetics of Suicide

The increasing number of suicidal victims all over the world is a major concern. There are three neurobiological systems involved in the pathophysiology of suicidal behavior: dysfunction of the serotonergic system, hyperactivity of the noradrenergic system, and increased activity of the hypothalamic–pituitary–adrenal (HPA) axis appear to be involved. Increasing evidence points to an overlap between neurobiological and cognitive psychological approaches to understanding suicidal behavior. The authors reviewed the molecular genetics of suicidal behavior. A better understanding of the neurobiology of suicide can help detect at-risk populations and help develop better treatment interventions. Because suicide continues to be a major public health problem, further studies are necessary, including research on the effects of combined medical and psychosocial approaches.