Carbohydrate metabolic disorder in experimental secretory diarrhea induced by cholera toxin

: Cholera toxin induced a massive mucus accumulation and a significant enhancement of arteriovenous difference in glucose concentration in the isolated loop of rabbit small intestine. Mucus hexosamine secretion increased threefold, whereas mucous lactate level remained unchanged. It is suggested that intensive mucus secretion is ensured by significant amounts of blood glucose, whose level is 65% increased, possibly due to the observed 1-6-fold liver gluconeogenesis acceleration. Though the mechanism of the latter is not yet known, the data obtained provide evidence that this stimulation is not cAMP-dependent.