Similarities between ischemic preconditioning and postconditioning in myocardial ischemia/reperfusion injury

Abstract Objective To determine whether a combination of ischemic preconditioning (IPreC) and ischemic postconditioning (IPostC) provided synergistic protection in myocardial ischemia/reperfusion injury. Methods and results IPreC and IPostC could not provide synergistically protective effects on reducing infarct size, inhibiting the increase of lactate dehydrogenase, creatine kinase and malondialdehyde and inhibiting the decrease of superoxide dismutase, and inhibiting myocardium apoptosis induced by ischemia/reperfusion. Conclusion The present study indicated that the combination of IPreC and IPostC could not provide a synergistic protection in myocardial 1ischemia/reperfusion injury, they may share common signaling pathways.