Synthesis, spectroscopic, structural and morphological characterizations of magnesium(II), calcium(II), strontium(II) and barium(II) folate complexes

Abstract This article aimed to synthesis and characterizations of metal folic acid as a vitamin B9 drug (H2FO) complexes. Using this bi-dentate ligand, complexes of magnesium(II), calcium(II), strontium(II) and barium(II) with general formula [M2(FO)(H2O)6(Cl)2].2H2O have been synthesized. The synthesized folate complexes were characterized by number of techniques using elemental analysis, molar conductance, (FTIR, Raman laser, 1HNMR & electronic) spectroscopy and particle size analysis using X-ray powder diffraction (XRD) spectra. The elemental analysis results suggest the stoichiometry to be 2 : 1 (M : L). All the synthesized complexes are non-electrolytic nature as confirmed by molar conductance measurements. Infrared spectral data indicate the coordination between the folate ligand and the central metal ion via the folate anion which acts as a dicarboxylate ligand with the metal ion coordinated to both the α and β carboxylate groups of the glutamic acid moiety. Spectral studies suggest six-coordination geometry for all complexes.