AIDS-Associated Infection Microsporidiosis, an Opportunistic the Treatment of Experimental Novel Synthetic Polyamines Are Effective in

Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocom-promised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We havedemonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents witha broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian