THE EFFECT OF SYNGENEIC TRANSFER OF NORMAL LYMPHOID CELLS ON THE DEVELOPMENT OF CASEIN‐INDUCED AMYLOIDOSIS IN MICE

Mouse amyloid induction with casein was accelerated by weekly injections of 108 syngeneic non-sensitized lymph node cells. Injections of spleen cells and of a mixture of thymus and bone marrow cells were without effect. A slight drop in the level of circulating casein-antibodies was noticed in mice having received lymph node cells. Two explanations of the acceleration were considered. An accelerating factor may be released from desintegrating lymph node cells or lymph node cells are producing the amyloid fibrils which later lodge in the spleen.