Inhibition of ergosterol biosynthesis in saccharomyces cerevisiae and Ustilago maydis by tridemorph, fenpropimorph and fenpropidin

Abstract The structurally related fungicides, tridemorph, fenpropimorph and fenpropidin have been shown to inhibit the sterol Δ 14 -reductase and Δ 8 →Δ 7 -isomerase during ergosterol biosynthesis in Saccharomyces cerevisiae and Ustilago maydis . However, although the three fungicides are able to inhibit both enzymes, tridemorph inhibits the Δ 8 -Δ 7 -isomerase better than the Δ 14 -reductase whilst the reverse is true for fenpropidin and to a lesser extent for fenpropimorph.