4-Aryl-1,3,2-oxathiazolylium-5-olate: A novel GST inhibitor to release JNK and activate c-Jun for cancer therapy

Purpose The over-expression of glutathion S-transferase Pi (GSTπ) in tumors and inhibitory effect of GSTπ to JNK are two possible causes of the development of drug-resistance in chemotherapy. This research is to develop a novel pH-controlled NO donor to inhibit GSTπ(and to activate the JNK/c-Jun pathway (omit “to induce apoptosis”).