Treatment plan modification using voxel-based weighting factors/dose prescription.
2003
Under various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The method uses a weighted quadratic dose objective function. The commonly used organ-/ROI-based weighting factors are expanded to a set of voxel-based weighting factors in order to obtain greater flexibility in treatment plan modification. Two different but equivalent modification schemes based on Rustem's quadratic programming algorithms—modification of a weighting matrix and modification of prescribed doses—are presented. Case studies demonstrated the effectiveness of the two methods with regard to their capability to fine-tune treatment plans.
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