Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry.

Mitul Patel,Balakumar Vijayakrishnan,Julia R. Koeppe,Justin M. Chalker,Katie J. Doores,Benjamin G. Davis

Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry.

2010

Mitul Patel
Balakumar Vijayakrishnan
Julia R. Koeppe
Justin M. Chalker
Katie J. Doores
Benjamin G. Davis

Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.

Keywords:

Mass spectrum
Sample preparation in mass spectrometry
Glycoprotein
MALDI-TOF Mass Spectrometry
Organic chemistry
Protein mass spectrometry
Carbohydrate loading
Chromatography
Chemistry
Dispersity
statistical correlation

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