TG-DTA of inclusion compound consisting of acetaminophen incorporated into 1D nanochannels of 2,4,6-tris(4-chlorophenoxy)-1,3,5-triazine

Abstract Inclusion compounds (ICs) have the potential to act as drug carriers. In this study, an IC consisting of acetaminophen incorporated into 2,4,6-tris(4-chlorophenoxy)-1,3,5-triazine (CLPOT) was synthesized ([CLPOT-acetaminophen]). Elemental analysis, 1H NMR spectroscopy and thermogravimetry-differential thermal analysis (TG-DTA), of the IC confirmed that ~0.1 acetaminophen molecules were included as guest molecules per CLPOT unit cell. The inclusion of acetaminophen in the 1D nanochannels of CLPOT was further confirmed by the DTA results of [CLPOT-acetaminophen], which showed the endothermal peak at 157 °C indicating the desorption of acetaminophen confined in the CLPOT nanochannels. These results suggest that CLPOT could be used as a stable microscopic carrier of biomaterials.