Effect of bunazosin on lower urinary tract function in the decerebrated dog

: The effect of bunazosin on the lower urinary tract function was studied by combined recording of cystometry and sphincter electromyogram (EMG) in 8 decerebrated dogs. Micturitions were induced by bladder filling and microelectrical stimulation of the pons before and after the administration of bunazosin. Bunazosin (0.03 mg/kg, i.v.) produced overflow incontinence in 7 of the 8 dogs and a significant decrease in the contractile response pressure to microelectrical stimulation of the pons in 6 dogs. Bunazosin appears to produce a decrease in urethral resistance and to be useful for the treatment of the failure of bladder emptying due to high urethral resistance.