Three component, regioselective, one-pot synthesis of β-hydroxytriazoles from epoxides via ‘click reactions’
2007
Abstract 2-Azidoalcohols derived in situ from epoxides and sodium azide undergo smooth coupling with alkynes under neutral conditions by means of ‘click reactions’ to furnish β-hydroxytriazoles in excellent yields and with high regioselectivity. This reaction proceeds smoothly in water at room temperature without the need for acid catalysis.
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