Evaluation of Teratogenic potentials of Bronchodilator drug on offsprings of Albino rats

The present study aimed to evaluate the teratogenic effects of the mucolytic and broncholytic drug (mucophylline) administered daily orally to the pregnant rats and nursing rats. The pregnant animals treated during the gestational period (5th – 18th day of gestation) with doses 30.83 mg/Kg and 66.61 mg/Kg the human equivalent dose (HED). On the 19th of gestation, the animals were sacrificed and the numbers of implanation sites, resorbed and live fetuses were counted. The fetal weight, length and tail length were recorded. Results showed decreased weight gain, fetal growth retardation during gestation period was dose dependent. Hematoma and anomalies of limbs were detected morphologically in the fetuses of maternally treated groups. Fetal skeletal abnormalities included lack of bones ossification as well as unossified centers of cervical, thoracic and sacral vertebrae and dumbelled shape vertebrae and bent ribs.