Colorectal Cancer: A Model for the Study of Cancer Immunology

Colorectal cancer is placed at the second place in terms of mortality by cancer. Even after the improvement and development in the colorectal cancer management, the prognosis of metastatic colorectal cancer is very poorly explored. And hence there is a requirement of very efficient, novel, and effective management strategies for the colorectal cancer, especially for metastatic colorectal cancer. Some of the recent studies has shown the efficacy of immunotherapy in some other types of tumors such as melanoma and the cancer of lungs and made this a practicable treatment strategy for the colorectal cancer and for clinical trials. The immunotherapy for the management of cancers is growing very rapidly due to advancement in the technological approaches. Here we are going to discuss the developmental status of immunotherapy for colorectal cancer. Some of the immunotherapy strategies which have shown success against the progression of colorectal cancer in some specific subsection of patients are different models for vaccine development, effector cell-based therapeutic strategies, and antibodies as checkpoint inhibition.