Endometrial Cancer: Advanced Stage

For patients with stage III/IV endometrial carcinoma, prognosis remains poor and an optimum therapy is yet to be established. Treatment is individualized based on disease extent at presentation, patient’s performance status, and hormonal status of the tumor. Surgery is often the mainstay of treatment in stage III disease. The role of adjuvant radiotherapy in conferring survival is controversial. Chemotherapy is fast emerging as an effective adjuvant treatment for advanced endometrial cancer. Hormonal therapy with variable response rates has been used for metastatic and recurrent endometrial carcinoma. The GOG continues to investigate multimodality therapy.