Synthesis of 2,2-Disubstituted Azaindolines by Intramolecular Cyclization in Acidic Media

Thomas-Xavier Metro,Christine Fayet,Florian Arnaud,Nathalie Rameix,Pierre Fraisse,Simon Janody,Mireille Sevrin,Pascal George,Rachel Vogel

Synthesis of 2,2-Disubstituted Azaindolines by Intramolecular Cyclization in Acidic Media

2011

Thomas-Xavier Metro
Christine Fayet
Florian Arnaud
Nathalie Rameix
Pierre Fraisse
Simon Janody
Mireille Sevrin
Pascal George
Rachel Vogel

The synthesis of a diverse array of 2,2-disubstituted azaindolines is reported. The bicyclic core is built by a simple acidic treatment of conveniently substituted aminopyridines.

Keywords:

Chemical synthesis
Aminopyridines
Bicyclic molecule
Photochemistry
Nucleophilic addition
Intramolecular force
Organic chemistry
Intramolecular reaction
Chemistry
Substituent
intramolecular cyclization

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