Study of changes in the levels of serum desmosine in smoking-induced acute exacerbation chronic obstructive pulmonary disease and its correlation with lung function

Objective To investigate the impact of smoking on the expression of serum desmosine (DES) and its relationship with chronic obstructive pulmonary disease (COPD). Methods Patients with AECOPD were divided into non-smoking COPD group and smoking COPD group, healthy smokers and healthy non-smokers were selected. After collecting venous blood, the serum concentration of desmosine was measured by enzyme-linked immunosorbent assay (ELISA), then the linear correlation analysis between desmosine and smoking index, pulmonary function indicator (FEV1%pred) was carried out. Results 1.The serum concentration of desmosine in smoking COPD group [(0.38±0.17)ng/ml] was significantly higher than that in non-smoking COPD group, smoking healthy group, and non-smoking healthy group [(0.29±0.08)ng/ml, (0.21±0.16)ng/ml, (0.15±0.07)ng/ml], with statistically significant differences (P<0.05). 2.The serum concentration of desmosine was positively correlated with smoking index (r=0.412, P<0.05), and negatively correlated with FEV1%pred (r=-0.348, P<0.05). Conclusion Smokers with COPD and non-smokers with COPD both had higher concentration of desmosine, especially the former. The serum concentration of desmosine was correlated with lung function indicator (FEV1%pred) in smokers with COPD. Key words: Pulmonary disease; Chronic obstructive; Acute exacerbation; Smoking; Desmosine; Serum