Anti‐cancer therapy: senescence is the new black

Cellular senescence is a natural safeguard against cancer. Pharmacologically, it can be induced by drugs that inhibit the CDK4/6 kinases such as palbociclib, but the exact mechanism has never been dissected. Recent research by Miettinen et al (2018) reveals that senescence induced by this class of drugs is mediated by proteasome hyper‐activation.