COMPOUNDED PREPARATIONS WITH NYSTATIN FOR ORAL AND OROMUCOSAL ADMINISTRATION

Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medici- nal products is their price, so the health care system and its payers may profit from extemporaneous com- pounding. An appropriate drug therapy for candidiasis (trush) is nystatin, which is a substance available in the Czech Republic for the magistral preparation relatively recently, since 2010. Making formulas for extempora- neous compounding is quite simple and preparations particularly useful for dentists, pediatricians, otolaryngol- ogists, oncologists and gastroenterologists. The authors formulated composition of viscous oromucosal sus- pension, oral/oromucosal hydrogel and oromucosal gelatine globule which may be present as compounded products containing nystatin for oromucosal and/or oral administration. The preparation is practically verified and magistral products have been already used in clinical practice.