The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

John Jonas Vytautas Duncia,Andrew T. Chiu,David John Carini,George B. Gregory,Alexander L. Johnson,William A. Price,Gregory J. Wells,Pancras C. Wong,Joseph C. Calabrese,Pieter B.M.W.M. Timmermans

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

1990

John Jonas Vytautas Duncia
Andrew T. Chiu
David John Carini
George B. Gregory
Alexander L. Johnson
William A. Price
Gregory J. Wells
Pancras C. Wong
Joseph C. Calabrese
Pieter B.M.W.M. Timmermans

A new class of potent antihypertensives has been discovered that exert their effect through blockade of the angiotensin II (AII) receptor. The compounds are nonpeptides. The synthesis as well as the pharmacological activity of the compounds are presented

Keywords:

Angiotensin II
Chemical synthesis
Antagonist
Angiotensin receptor
Angiotensin II receptor antagonist
Blockade
Pharmacology
Biological activity
Chemistry
Endocrinology
Receptor
Internal medicine
Stereochemistry
Ligand (biochemistry)
Peptide

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

230

Citations