Methods to Regulate GABAA Receptor and the Development of Relevant Pharmacotherapy on Neurological and Psychiatric Disorders

GABAA receptor(GABAAR)is recognized as one of the important inhibitory receptors which contibutes to the pathogenesis and treatment of several neurological and psychiatric disorders including depression,anxiety,epilepsy,dysmnesia and drug dependence.The profound inestigation of GABAAR also reveals other functions correlating with sedation,analgesia and muscle relaxation.Here is to summarize its regulation mechanism and relevant deseases from three aspects:the relevance of GABAAR′s subunits and binding sites,GABAAR′s anabolism and its feedback regulation with HPA aixs.