Generation of a Specific Immunological Response to FGF‐2 Does Not Affect Wound Healing or Reproduction

Angiogenesis, the process of new capillary formation from pre‐existing vessels, has been established as an important mechanism involved in pathologic processes, such as cancer, as well as in normal physiology (Ribatti, D.; Vacca, A.; Roncali, L.; Dammacco, F. Angiogenesis under normal and pathological conditions. Haematologica 1991, 76 (4), 311–320). Basic fibroblast growth factor (FGF‐2) is a critical mediator of angiogenesis that is important for normal reproduction and wound healing. FGF‐2 mediates its pro‐angiogenic effects by binding to heparin sulfate proteoglycan in addition to a tyrosine kinase receptor (Baird, A.; Schubert, D.; Ling, N.; Guillemin, R. Receptor and heparin‐binding domain of basic fibroblast growth factor. Proc. Natl. Acad. Sci. U. S. A. 1998, 5 (7), 2324–2328; Richard, C.; Roghani, M.; Moscatelli, D. Fibroblast growth factor (FGF)‐2 mediates cell attachment through interactions with two FGF receptor‐1 isoforms and extracellular matrix or cell‐associated heparin sulfate proteoglyca...