Activated protein C resistance and pregnancy - Department's of Haematology, Coltea Clinical Hospital experience

Activated Protein C resistance (APCR) is the most frequency trombophilia that induces thrombotic complications of pregnancy that itself is a hypercoagulable state. Abnormal placental vasculature is the most important mechanism that causes various complications. The screening diagnosis of APCR is influenced by physiological changes of hemostasis in pregnancy and may be difficult. We propose to evaluate the risk for thrombosis complications associated with the factor V Leiden mutation in pregnancy, using a lot of women with complications of pregnancy selected from our casuistic. We concluded that factor V Leiden mutation and resistance to activated protein C are important risk factors for pregnancy complications. The screening for resistance to activated protein C with FV deficiency plasma is recommended in all pregnant women with vascular placental complications or history of pregnancy complications.