EFFECT OF SCHIFF BASE LIGAND AND TRANSITION METAL COMPLEXES ON SEX HORMONES, SPERM DYNAMICS AND FERTILITY IN MALE ALBINO RATS

The novel organotitanium(IV) and organozirconium(IV) complexes have been synthesized by reacting Cp2TiCl2 and Cp2ZrCl2 with sulphur donor ligand (N ' -(1-2-oxo-2H- chrome-3yl-ethylidene)-hydrazinecarbodithionic acid benzyl ester) and characterized on the basis of IR,UV, 1 H NMR and 13 C NMR spectral studies, elemental analysis and molecular weight determinations. Zirconium and titanium were estimated by gravimetrical method. The present research was coined at investigating the effects of metal complexes on the hormones and sperm profile in male albino rats. The effects of complexes on sex hormones, sperm density, sperm motility and fertility were observed at dose level of 30 mg/kg.b.wt./day for 45 days in male albino rats. Findings of the present investigation mention a highly significant decrease in testosterone, follicle stimulating hormone (FSH) and leutinizing hormone (LH). Decrease in sperm motility and sperm density was observed after complexes exposure, as compared to control group. Decrease in the weight of testes, epididymis, vas deferens, and seminal vesicle were also observed. In conclusion the study shows that ligand (N ' -(1-2-oxo-2H-chrome-3yl- ethylidene)-hydrazinecarbodithionic acid benzyl ester) and its metal complexes alter the sex hormones and fertility in rats.