Activin novel receptor and uses thereof

A nucleic acid molecule isolated comprising a polynucleotide selected from the group queconsiste in: (a) a polynucleotide having the polynucleotide sequence set forth in SEQ ID NO: 1 or the complement thereof; (b) a polynucleotide encoding a polypeptide consisting of the amino acid sequence set forth in SEQID NO: 2; (c) the polynucleotide sequence that hybridizes to (a) or (b) under conditions of moderate stringency enaproximadamente 50% formamide, 6X SSC at about 42 ° c and wash conditions deaproximadamente 60 ° C, 0.5X SSC, 0.1% SDS and wherein the encoded polypeptide comprises a extremoC having an amino acid sequence set forth in SEQ ID NO: 3 and wherein the polypeptide is capable deunirse myostatin, activin A or GDF-11; and (d) the polynucleotide sequence that hybridizes to (a) or (b) moderate stringency conditions enaproximadamente 50% formamide, 6X SSC at about 42 ° C and wash conditions deaproximadamente 60 ° C, 0.5X SSC, SDS 0.1% and wherein the encoded polypeptide comprises a extremoC having an amino acid sequence at least 80% identical to SEQ ID NO: 3 and wherein the polipeptidoes capable of binding myostatin, activin a or GDF eleven.