Mast cell mediation of muscle and pulmonary injury following hindlimb ischemia-reperfusion.

ited a significant increment in permeability during hindlimb reperfusion. In lungs of the same mice, mast cell-derived chymase mMCP-1 coats alveolar macrophages, an event noted by us in acid-induced direct lung injury. Mast cells in the lung contain mMCP-1, whereas those in the muscle do not. Neither extensive muscle injury nor an increased pulmonary permeability index occurs in the mast cell-deficient W/W v mice. We conclude that the mast cell is a key mediator in both local ischemia‐reperfusion injury (I‐R) of muscle and conse