91 TOTAL PARENTERAL NUTRITION ASSOCIATED PHOSPHOLIPIDOSIS OF THE LIVER IN INFANTS

A variety of histologic aspects have been reported to occur during the course of parenteral nutrition(PN)in pediatrics as well as in adults patients. Phospholipidosis has been described with drugs administration. After a month of TPN we studied liver histology in 7 infants ranged from 2 to 8 months. All were without any previous liver disease and presented protracted diarrhea requiring bowel rest. PN Provided daily nitrogen(602±37mg/kg)and no protein energy(369±51KJ/kg) intakes, without intravenous fat emulsion during the first month. In addition to repeated liver function tests, we performed percutaneous liver biopsy after 30 PN days, using Hepafix needle(1,4mm). Liver specimens were fixed in buffered formalin and stained using lipids histochemistry:oil red O,Nils blue, Holczinger, Adams and Baker OTAN.