Change in serum prostate specific antigen values in men who had no evidence of prostate cancer on initial biopsy

: To determine the need for repeat prostatic biopsy, we retrospectively evaluated 19 men for longitudinal prostate specific antigen (PSA) for more than 20 weeks from initial biopsy. Their initial biopsy results revealed no evidence of prostatic cancer. They had no surgical therapy or hormone therapy after it. If they had a 50% increase in the PSA level from initial biopsy, we performed the second biopsy. Of the 5 men who had the second biopsy, 3 men had prostatic cancer.