CD10 Expression in Primary Intestinal Large B-Cell Lymphomas

Abstract Objective.—To determine the prevalence and clinical significance of a follicular origin in primary intestinal large B-cell lymphomas. Design.—We performed immunohistochemistry for detection of CD10 and Bcl-6 in paraffin-embedded tissue sections from 32 patients who had surgically resected primary intestinal lymphomas. We then correlated the expression of CD10 protein with various clinical parameters. Results.—Fifteen of 32 cases (47%) were CD10+, and CD10 positivity was correlated with intense Bcl-6 positivity. There were no significant differences in age, sex, serum lactate dehydrogenase level, and performance status between the CD10+ and CD10− groups. Patients with CD10+ lymphoma more frequently presented with stage I2 disease compared with those with CD10− lymphoma (P = .03). The response to treatment was significantly better in the CD10+ group than in the CD10− group (P = .02). An analysis of survival rates showed a trend for a longer overall survival duration in the CD10+ group compared with...