The expression and clinical significance of MyD88 in human ovarian carcinomas

Objective To examine the expression and clinical significance of MyD88 in ovarian carcinomas. Methods Specimens from 115 patients with ovarian carcinomas managed in our hospital between Augest 2000 and February 2010 were included in this study. Immunohistochemical staining was used to detect the expression of MyD88 in ovarian carcinomas and normal tissues. All the specimens were confirmed by pathology for ovarian carcinomas and normal tissues by HE staining. The correlation between the expression and clinical significance of patients was analyzed. Results The positive expression rate of MyD88 in ovarian carcinomas and normal tissues was 70.4% and 23.5%, respectively. MyD88 expression was significantly associated with tumor stage and distant metastasis (P<0.05). According to the survival analysis of 115 ovarian carcinomas patients, cases in the MyD88 positive-expression group showed poorer overall survival rate when compared with negative-expression group (P<0.001). Conclusion These results indicate that the expression of MyD88 was related with in the progression of ovarian carcinomas and may have clinical utility in the prediction of prognosis of ovarian carcinomas. Key words: Ovarian neoplasms; Cyeokines; MyD88