Procedure for obtaining 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazoles.

Process for preparing 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazoles. The process for the preparation of 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzo-thiazoles (I) wherein the asterisk (*) denotes an asymmetric carbon and R1 is C1-C6 alkyl; its enantiomers or mixtures thereof, its solvates, hydrates or pharmaceutically acceptable salts, comprising: (a) reacting a compound (II) with a secondary amine, optionally in the presence of an acid and a solvent 1, to form an enamine; (B) optionally removing said acid and said solvent 1, and then reacting said enamine with sulfur in the presence of a solvent 2; and (c) reacting the compound previously obtained with cyanamide to obtain the compound (I). Among the compounds (I) is pramipexole, a compound with agonist activity of dopamine D-2, useful for the treatment of Parkinson's disease and schizophrenia.