Getting Warmer: Following One's Gut to Build Bone.

In this issue of the Cell Metabolism, Chevalier et al. show that a warm environment produces changes in the composition of intestinal microbiota and that these changes can prevent bone loss due to hypogonadism. Dovetailing with prior studies on the ability of probiotics to reverse hypogonadism-induced osteopenia, the findings reaffirm a central role for the microbiome in regulating bone mass in response to both environmental and hormonal cues.