환경오염 물질인 메타미포프의 정제 및 다양한 순도 결정 방법을 통한 표준물질 제조 연구

In this study, we purified an environmental pollutant (metamifop) by re-crystallization under various conditions and prepared four kinds of high-purity reference materials (RM) that show small variations in purity among each other. To measure their purities with uncertainty, four different analytical methods were employed: differential scanning calorimetry (DSC), peak area normalization (HPLC), external calibrant (HPLC), and quantitative NMR (q-NMR). The highest purity of metamifop RM, determined by q-NMR, was 99.02% with an uncertainty of 0.64% compared with 99.36% (with 0.12% uncertainty), 99.46% (with 0.53% uncertainty) and 99.84% (with 0.29% uncertainty), determined by DSC, external calibrant, and peak area normalization, respectively. Most of the evaluated purities are within the calculated uncertainty range.