Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics

Shanshan Jiang,Qihong Rui,Yu Wang,Hye Young Heo,Tianyu Zou,Hao Yu,Yi Zhang,Xianlong Wang,Yongxing Du,Xinrui Wen,Fangyao Chen,Jihong Wang,Charles G. Eberhart,Jinyuan Zhou,Zhibo Wen

Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics

2018

Shanshan Jiang
Qihong Rui
Yu Wang
Hye Young Heo
Tianyu Zou
Hao Yu
Yi Zhang
Xianlong Wang
Yongxing Du
Xinrui Wen
Fangyao Chen
Jihong Wang
Charles G. Eberhart
Jinyuan Zhou
Zhibo Wen

Objectives To explore the feasibility of using amide proton transfer-weighted (APTw) MRI metrics as surrogate biomarkers to identify the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status in glioblastoma (GBM).

Keywords:

Methylation
Radiology
Glioblastoma
Amide
Cancer research
Magnetic resonance imaging
Biomarker (medicine)
Medicine
Methyltransferase
amide proton
Pathology
mgmt promoter methylation
in patient

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